Stefania Evoli
Application Scientist Insilico Medicine
Computational Biophysicist with more than 15 years of experience in molecular modeling, molecular dynamics, molecular docking and free energy calculations in both biology and small molecule systems. Worked with clients from biotech, pharma and food industry for over 5 years.
Seminars
Thursday 27th August 2026
Benchmarking Antibody-Antigen Affinity Prediction Across Sequence-, Structure-, & Physics-Based Methods
10:00 am
- Structure-aware approaches outperform sequence-based models, highlighting the importance of explicit 3D epitope–paratope interactions
- PLM and LLM methods underperform overall, indicating limits of sequence-only representations for binding affinity prediction
- Reliable prediction remains driven by structural and physicochemical information, with hybrid approaches showing the most promise
