In Silico Developability Assessment for Guided Formulation of Biologics

• Sequence and structure-based in silico modeling enables early, interpretable assessment of key developability liabilities in biologics
• MD simulations refine property predictions by accounting for conformational dynamics and solution-dependent behavior
• Coupling computational predictions with physicochemical and MS data supports guided, risk-informed formulation development

Speakers:

Shukun Luo

Principal Scientist

Regeneron