De Novo Designed Protein Agonist Targeting a Heterodimer Without a Solved Structure

• Exploring how a de novo protein was designed to target a heterodimeric receptor in the absence of a solved structure
• Achieving biased agonism with a de novo protein
• Emphasizing the importance of a human-in-the-loop AI/ML pipeline for biologics design

Speakers:

Lindsay Hammack

Associate Principal Scientist

Merck