Benchmarking AI-Enabled Protein Design Across Complex Biologics Formats: From Function to Manufacturability

• Defining format-aware benchmarking strategies to quantitatively evaluate AI/CDD performance for complex protein therapeutics across function, developability, and manufacturability
• Integrating AI-driven protein design with experimental data generation to optimize for biological activity and CMC-relevant properties across bispecifics, multispecifics, and ADCs
• Addressing nuanced data generation, standardization, and scaling challenges relevant to complex proteins to improve predictive accuracy for stability, aggregation, and functional performance in advanced protein formats

Speakers:

Joel Karpiak

Head, Protein Design & Informatics

GSK