Application of AI/ML for Predicting CIEX Binding Differences of mAb Building Blocks

• Sequence pI, the most widely used CIEX binding predictor is a poor predictor of binding to CIEX
• LLM descriptors can be used to predict aCIEX retention time
• 100s of aCIEX data points and their sequence, structure and pLLM based features can be leveraged for selecting and/or designing mAb building blocks

Speakers:

Pranav Khade

Scientist, Computational Biologics Design

Gilead Sciences